Selected Publications 2023 1. Chauhan NR, Kundu S, Chattopadhyay D, Bal R… Chauhan S*. Transgenic Mouse Models Support a Protective Role of Type I IFN Response in SARS-CoV-2 infection-related Lung Immunopathology and Neuroinvasion. Cell Reports, 2023. doi.org/10.1016/j.celrep.2023.113275.
Mehto S, Jena KK , Yadav R, Priyadarsini S, Samal P, Krishna S, Dhar K, Jain A, Chauhan NR, Murmu KC, Bal R, Sahu R, Jaiswal P, Sahoo BS, Patnaik S, Kufer TS, Rusten TE, Chauhan S, Prasad P, Chauhan S*. Selective Autophagy of RIPosomes Maintains Innate Immune Homeostasis during Bacterial Infection. EMBO JDec 1;41(23):e111289. (Cover page article)
Saha S, Samal P, Madhulika S, Murmu KC, Chakraborty S, Basu J, Barik S, Jena KK, Das A, Chauhan S, Prasad P. SMARCD1 negatively regulates myeloid differentiation of leukemic cells via epigenetic mechanisms. Blood Adv. 2022. May 24;6(10):3106-3113
Nath P, Chauhan NR, Jena KK, Datey A, Kumar ND, Mehto S, De S, Nayak TK, Priyadarsini S, Rout K, Bal R, Murmu KC, Kalia M, Patnaik S, Prasad P, Reggiori F, Chattopadhyay S*, Chauhan S*. Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses. EMBO Rep. 2021. * Corresponding author. (Cover page article)
2. Kolapalli SP, Sahu R, Chauhan NR, Jena KK, Mehto S, Das SK, Jain A, Rout M, Dash R, Swain RK, Lee DY, Rusten TE, Chauhan S*, Chauhan S*. RNA binding RING E3-ligase DZIP3/hRUL138 is a novel driver of cell cycle and cancer progression by employing a unique mechanism to stabilize Cyclin D1. Cancer Research, 2021 Jan 15;81(2):315-331. * Corresponding author. (Cover page article)
Mehto S, Jena KK, Nath P, Chauhan S, Kolapalli SP, Das SK, Sahoo PK, Jain A, Taylor GA, Chauhan S*. The Crohn's disease risk factor IRGM limits NLRP3 inflammasome activation by impeding its assembly and by mediating its selective autophagy. Molecular Cell. 2019 Feb 7;73(3):429-445.e7.* Corresponding authorPreview: Nabar NR, Kehrl JH. Inflammasome Inhibition Links IRGM to Innate Immunity. Mol Cell. 2019 Feb 7;73(3):391-392.
Mehto S, Chauhan S, Jena KK, Chauhan NR, Nath P, Sahu R, Dhar K, Das SK, Chauhan S*. IRGM restrains NLRP3 inflammasome activation by mediating its SQSTM1/p62-dependent selective autophagy. Autophagy. 2019 Jun 20:1-3.* Corresponding author
Jena KK, Mehto S, Kolapalli SP, Nath P, Sahu R, Chauhan NR, Sahoo PK, Dhar K, Das SK, Chauhan S, Chauhan S*. TRIM16 governs the biogenesis and disposal of stress-induced protein aggregates to evade cytotoxicity: implication for neurodegeneration and cancer. Autophagy. 2019 May;15(5):924-926.* Corresponding author.
Jena KK, Kolapalli SP, Mehto S, Nath P, Das B, Sahoo PK, Ahad A, Syed GH, Raghav SK, Senapati S, Chauhan S, Chauhan S*. TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. EMBO J. 2018 Sep 14;37(18).
Selected papers as Postdoc and PhD 2017
Kumar S, Chauhan S, Jain A, Ponpuak M, Choi SW, Mudd M, Peters R, Mandell MA, Johansen T, Deretic V. Galectins and TRIMs directly interact and orchestrate autophagic response to endomembrane damage. Autophagy. 2017 Jun 3;13(6):1086-1087.
1. Santosh Chauhan*, Marisa Ponpuak*, Ashish Jain*, Suresh Kumar*, Michal H. Mudd, Tomonori Kimura, Seong Won Choi, Ryan Peters, Michael Mandell, Terje Johansen, and Vojo Deretic. TRIMs and Galectins globally cooperate and TRIM16 and Galectin-3 codirect autophagy in endomembrane damage homeostasis. Developmental Cell, 2016. Preview in Developmental cell : A TRIM16-Galectin3 Complex Mediates Autophagy of Damaged Endomembranes. Milana Fraiberg, Zvulun Elazar. 2015
Santosh Chauhan*, Zahra Ahmed*, Steven B. Bradfute,….Vincent Piguet, and Vojo Deretic. Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential. * Equal authorships. Nature Communication. 2015 Oct 27;6:8620. doi: 10.1038/ncomms9620.
Chauhan, S.*, Mandell, M. and Deretic, V.*. IRGM governs the core autophagy machinery to conduct antimicrobial defense. Volume 58, Issue 3, p507–521, 7 May, Molecular Cell. * Corresponding author.
Chauhan S, Mandell MA, Deretic V. Mechanism of action of the tuberculosis and Crohn disease risk factor IRGM in autophagy. Autophagy. 2015 Aug 27:0. PMID: 26313894
Mandell MA, Jain A, Arko-Mensah J, Chauhan S, Kimura T, Dinkins C, Silvestri G, Münch J, Kirchhoff F, Simonsen A, Wei Y, Levine B, Johansen T, Deretic V. TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. Developmental Cell. 2014 Aug 25; 30(4):394-409.
Dupont N, Chauhan S, Arko-Mensah J, Castillo EF, Masedunskas A, Weigert R, Robenek H, Proikas-Cezanne T, Deretic V. Neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis. Current Biology (Cell Press). 2014 Mar 17;24 (6):609-20.
Chauhan, S., Goodwin, J.G., Chauhan, S., Manyam, G., Wang, J., Kamat, A.M., and Boyd, D.D. (2013). ZKSCAN3 Is a Master Transcriptional Repressor of Autophagy. Molecular Cell. Apr 11;50(1):16-28. Highlighted in Cancer Discovery (AACR) journal, February 28, 2013; doi:10.1158/2159-8290.CD-RW2013-046. Recommended by Faculty of 1000 (http://f1000.com/prime/717980675)
Chauhan, S., and Boyd DD. Regulation of u-PAR gene expression by H2A.Z is modulated by the MEK-ERK/AP-1 pathway. Nucleic Acids Research. 2012 Jan; 40 (2):600-13.
Chauhan, S., Sharma, D., Singh, A., Surolia, A. and Tyagi, J.S. Comprehensive insights into Mycobacterium tuberculosis DevR (DosR) regulon activation switch. Nucleic Acids Research. 2011 Sep 1;39(17):7400-14.
Chauhan, S and Tyagi, J.S. (2011) Analysis of transcription at the oriC locus in Mycobacterium tuberculosis. Microbiol Res. 2011 Sep 20;166(6):508-14.
Gupta, R.K., Chauhan, S. and Tyagi, J.S. K182G substitution in DevR or C(8) G mutation in the Dev box impairs protein-DNA interaction and abrogates DevR-mediated gene induction in Mycobacterium tuberculosis. FEBS J. 2011 Jun; 278(12):2131-9.
Chauhan S, Singh A, Tyagi JS. A single-nucleotide mutation in the -10 promoter region inactivates the narK2X promoter in Mycobacterium bovis and Mycobacterium bovis BCG and has an application in diagnosis. FEMS Microbiol Lett. 2010, Feb;303(2):190-6.
Chauhan S, Tyagi JS. Powerful induction of divergent tgs1-Rv3131 genes in Mycobacterium tuberculosis is mediated by DevR interaction with a high-affinity site and an adjacent cryptic low-affinity site. Journal of Bacteriology. 2009, Oct;191(19):6075-81.
Chauhan S, Kumar A, Singhal A, Tyagi JS, Krishna Prasad H. CmtR, a cadmium-sensing ArsR-SmtB repressor, cooperatively interacts with multiple operator sites to autorepress its transcription in Mycobacterium tuberculosis. FEBS J. 2009, Jul; 276(13):3428-39.
Chauhan S, Tyagi JS. Interaction of DevR with Multiple Binding Sites Synergistically Activates Divergent Transcription of narK2-Rv1738 Genes in Mycobacterium tuberculosis. Journal of Bacteriology. Aug 2008, p. 5394–5403, 190, No. 15.
Chauhan S, Tyagi JS. Cooperative binding of phosphorylated DevR to upstream sites is necessary and sufficient for activation of the Rv3134c-devRS operon in Mycobacterium tuberculosis: Implication in the induction of DevR target genes. Journal of Bacteriology, June 2008, p. 4301–4312, 190, No.12.
Bagchi G*, Chauhan S*, Sharma D, Tyagi JS. Transcription and autoregulation of Rv3134c-devR-devS operon of Mycobacterium tuberculosis. Microbiology (2005), 151, 4045-4053. *Equal contribution to work.